So what are some of the symptoms of heart disease that we can look out for? Some of them are pretty basic. They would be chest pressure or pain, shortness of breath, lower extremity edema, or palpitations. If we talk a little bit about each one, chest pain can sometimes be confusing. When doctors reference pain, we're not always talking about a sharp discomfort in the chest. As a matter of fact, sometimes pressure or discomfort in the chest, would be more concerning. In terms of shortness of breath, it could be either shortness of breath at rest, or when you try to exert yourself, such as going up a flight or two of stairs... .